3D-structure - 5HYN:
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Entry | 5hyn | |
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Header | TRANSFERASE
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Title | STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH HISTONE H3K27M PEPTIDE |
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Authors | N. JUSTIN, Y. ZHANG, C. TARRICONE, S. R. MARTIN, S. CHEN, E. UNV. DEMARCO, L. F. HAIRE, P. A. WALKER, D. REINBERG, J. R. WILSS. J. GAMBLIN |
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Primary Title | STRUCTURAL BASIS OF ONCOGENIC HISTONE H3K27M INHIBI
HUMAN POLYCOMB REPRESSIVE COMPLEX 2. |
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Reference | NAT, COMMUN, , V.7, 11316, 2016 |
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Experiment | Method: X-RAY DIFFRACTION
Parameters: Resolution: 2.95 Angs, Ref-Value: 22.2, Space Group: P 21 21 21
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Chains | A, F, K, Q, B, G, L, R, C, H, M, S, D, I, O, T, E, J, P, U |
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Biological Unit | Biological Unit as provided by the RCSB PDB |
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Pentamer 1: | A B C D E | |
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Pentamer 2: | F G H I J | |
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Pentamer 3: | K L M O P | |
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Pentamer 4: | Q R S T U | |
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Tetramer 5: | A B C D | |
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Tetramer 6: | F G H I | |
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Tetramer 7: | K L M O | |
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Tetramer 8: | Q R S T | |
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Enzyme | 2.1.1.43 (Name(s) and Reaction(s) catalysed) |
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Source | Homo sapiens |
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Taxonomy | 9606 |
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UniProt | Chain A: Q15910,Chain B: O75530,Chain C: Q15022,Chain D: 21 33,Chain E: 1 12,Chain F: Q15910,Chain G: O75530,Chain H: Q15022,Chain I: 21 33,Chain J: 1 12,Chain K: Q15910,Chain L: O75530,Chain M: Q15022,Chain O: 21 33,Chain P: 1 12,Chain Q: Q15910,Chain R: O75530,Chain S: Q15022,Chain T: 21 33,Chain U: 1 12, |
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| Geometry: [Spots in Red indicate possible wrong φ & ψ values]
| | 3D-View - PDBe Mol*
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