Title: Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. |
Journal: The Biochemical journal. 2003 Feb;370(Pt 1):29-34 |
Authors: Soubeyran P, Barac A, Szymkiewicz I, Dikic I. |
Abstract: The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2. |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/12475393 |