Title: Action of RORs and their ligands in (patho)physiology. | Journal: Trends in endocrinology and metabolism: TEM. 2012 Dec;23(12):619-27 | Authors: Solt LA, Burris TP. | Abstract: The retinoic-acid-receptor-related orphan receptors (RORs) are members of the nuclear receptor (NR) superfamily whose activity has been implicated in several physiological and pathological processes. The RORs, specifically RORĪ± and RORĪ³, are considered to be master regulators of T(H)17 cells, a recently described subset of CD4(+) T helper cells that have been demonstrated to have a pathological role in autoimmune disease. As with most members of the NR superfamily, RORs are ligand-regulated, suggesting that their activity can be modulated by synthetic ligands. Recent advances in the field have established that selective inhibition of the RORs is a viable therapeutic approach for not only the treatment of autoimmune disorders but also ROR-mediated metabolic disorders. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/22789990 |
|