Title: Outer membrane protein 25-a mitochondrial anchor and inhibitor of stress-activated protein kinase-3. | Journal: Biochimica et biophysica acta. 2005 May;1744(1):68-75 | Authors: Court NW, Ingley E, Klinken SP, Bogoyevitch MA. | Abstract: Stress-activated protein kinase-3 (SAPK3) is unique amongst the mitogen-activated protein kinase (MAPK) family with its C-terminal 5 amino acids directing interaction with the PDZ domain-containing substrates alpha1-Syntrophin and SAP90/PSD95. Here, we identify three additional PDZ domain-containing binding partners, Lin-7C, Scribble, and outer membrane protein 25 (OMP25). This latter protein is localised together with SAPK3 at the mitochondria but it is not a SAPK3 substrate. Instead, OMP25 inhibits SAPK3 activity towards PDZ domain-containing substrates such as alpha1-Syntrophin and substrates without PDZ domains such as the mitochondrial protein Sab. This is a new mechanism for the regulation of SAPK3 and suggests that its intracellular activity should not be solely assessed by its phosphorylation status. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/15878399 |
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