Title: SLURP-1 modulates corneal homeostasis by serving as a soluble scavenger of urokinase-type plasminogen activator. |
Journal: Investigative ophthalmology & visual science. 2014 Aug;55(10):6251-61 |
Authors: Swamynathan S, Swamynathan SK. |
Abstract: Our previous study revealed the immunomodulatory property of the secreted lymphocyte antigen (Ly6)/urokinase-type plasminogen activator receptor (uPAR)-related protein-1 (SLURP1), abundantly expressed in the cornea and associated with the hyperkeratotic disorder Mal de Meleda. Here, we test the hypothesis that SLURP1 modulates the functions of membrane-tethered uPAR by acting as a soluble scavenger of its ligand urokinase-type plasminogen activator (uPA). |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/25168896 |