Title: t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. | Journal: Leukemia research. 2005 Apr;29(4):467-70 | Authors: Morerio C, Acquila M, Rosanda C, Rapella A, Tassano E, Micalizzi C, Panarello C. | Abstract: The rare t(9;11)(p22;p15) translocation is associated with adult acute myeloid leukemia (AML) with immature forms. We report a novel fusion of the NUP98 and LEDGF genes in a pediatric AML with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes exhibiting the same chromosomal rearrangement. Fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR) studies identified the chimeric transcript product of in-frame fusion of NUP98 exon 8 to LEDGF exon 4. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/15725483 |
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