Title: Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice. | Journal: Arteriosclerosis, thrombosis, and vascular biology. 2012 Jul;32(7):1577-84 | Authors: Li Z, Fan Y, Liu J, Li Y, Huan C, Bui HH, Kuo MS, Park TS, Cao G, Jiang XC. | Abstract: Sphingomyelin synthase (SMS) catalyzes the conversion of ceramide to sphingomyelin and sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. Although they have the same SMS activity, they are different enzymes with distinguishable subcellular localizations and cell expression patterns. It is conceivable that these differences could yield different consequences, in terms of sphingolipid metabolism and its related atherogenesis. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/22580896 |
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