Title: Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity. | Journal: Thrombosis research. 2013 Jun;131(6):535-9 | Authors: Nahar R, Dube D, Parakh R, Deb R, Saxena R, Singh TP, Verma IC. | Abstract: Polymorphisms in CYP2C9 can vary the rate of metabolic clearance of oral anticoagulants, risking toxicity in patients. The present study focused on exploring the genetic etiology of idiopathic hyper sensitivity to coumarin anticoagulants in a patient who presented with multiple bleeding episodes and supra-elevated International Normalized Ratios. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/23582453 |
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