Title: Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli. |
Journal: BMC microbiology. 2013 Feb;13():45 |
Authors: Kasari V, Mets T, Tenson T, Kaldalu N. |
Abstract: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons. Transcription of multiple TA operons is activated in temporarily non-growing persister cells that can resist killing by antibiotics. Consequently, the antitoxin levels of persisters must have been dropped and toxins are released of inhibition. |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/23432955 |