Title: DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli. |
Journal: Journal of bacteriology. 1990 Dec;172(12):7260-2 |
Authors: Sreedharan S, Oram M, Jensen B, Peterson LR, Fisher LM. |
Abstract: The gyrA genes isolated from three ciprofloxacin-resistant clinical isolates of Staphylococcus aureus carried codon 84 (serine----leucine) and/or codon 85 (serine----proline) mutations that were absent in pretreatment susceptible strains. These substitutions occur in a region of the gyrase A protein wherein directly analogous mutations of serine 83----leucine and alanine 84----proline in Escherichia coli confer quinolone resistance. Thus, DNA gyrase A subunit mutations are implicated in resistance to ciprofloxacin in S. aureus. |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/2174869 |