Title: Persisters: a distinct physiological state of E. coli. | Journal: BMC microbiology. 2006 Jun;6():53 | Authors: Shah D, Zhang Z, Khodursky A, Kaldalu N, Kurg K, Lewis K. | Abstract: Bacterial populations contain persisters, phenotypic variants that constitute approximately 1% of cells in stationary phase and biofilm cultures. Multidrug tolerance of persisters is largely responsible for the inability of antibiotics to completely eradicate infections. Recent progress in understanding persisters is encouraging, but the main obstacle in understanding their nature was our inability to isolate these elusive cells from a wild-type population since their discovery in 1944. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/16768798 |
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