Title: A novel DNA-binding motif in MarA: the first structure for an AraC family transcriptional activator. |
Journal: Proceedings of the National Academy of Sciences of the United States of America. 1998 Sep;95(18):10413-8 |
Authors: Rhee S, Martin RG, Rosner JL, Davies DR. |
Abstract: A crystal structure for a member of the AraC prokaryotic transcriptional activator family, MarA, in complex with its cognate DNA-binding site is described. MarA consists of two similar subdomains, each containing a helix-turn-helix DNA-binding motif. The two recognition helices of the motifs are inserted into adjacent major groove segments on the same face of the DNA but are separated by only 27 A thereby bending the DNA by approximately 35 degrees. Extensive interactions between the recognition helices and the DNA major groove provide the sequence specificity. |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/9724717 |