Title: Combined inactivation of lon and ycgE decreases multidrug susceptibility by reducing the amount of OmpF porin in Escherichia coli. | Journal: Antimicrobial agents and chemotherapy. 2009 Nov;53(11):4944-8 | Authors: Duval V, Nicoloff H, Levy SB. | Abstract: Transposon inactivation of ycgE, a gene encoding a putative transcriptional regulator, led to decreased multidrug susceptibility in an Escherichia coli lon mutant. The multidrug susceptibility phenotype (e.g., to tetracycline and beta-lactam antibiotics) required the inactivation of both lon and ycgE. In this mutant, a decreased amount of OmpF porin contributes to the lowered drug susceptibility, with a greater effect at 26 degrees C than at 37 degrees C. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/19721064 |
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