Title: Ciprofloxacin resistance in coagulase-positive and -negative staphylococci: role of mutations at serine 84 in the DNA gyrase A protein of Staphylococcus aureus and Staphylococcus epidermidis. |
Journal: Antimicrobial agents and chemotherapy. 1991 Oct;35(10):2151-4 |
Authors: Sreedharan S, Peterson LR, Fisher LM. |
Abstract: gyrA mutations in quinolone-resistant pathogenic isolates of Staphylococcus spp. have been detected by the direct HinfI digestion of polymerase chain reaction products. Homology among gyrA genes allowed rapid examination of both coagulase-positive and -negative isolates. DNA sequence analysis revealed that ciprofloxacin resistance in Staphylococcus epidermidis is associated with a novel Ser-84----Phe mutation in the DNA gyrase A protein, analogous to Ser-84----Leu changes observed in Staphylococcus aureus. |
See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/1662027 |