Title: Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11. | Journal: The Journal of antibiotics. 2008 Oct;61(10):633-7 | Authors: Zheng CJ, Yu HE, Kim EH, Kim WG. | Abstract: A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (microg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline. | See full PubMed entry: http://www.ncbi.nlm.nih.gov/pubmed/19168978 |
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