CacSFMs: Citric Acid Cycle Binding Structural & Functional Motifs - v. β May 2016.
© University Dr Tahar Moulay, Saida.



Project realized by:Abdalla Salem and Mubarka Khatir (in their project of MSc in Biology, 2015-2016)

Proposed & supervised by: Dr. Abdelkrim Rachedi, e-mail: rachedi@bioinformaticstools.org

Reference: SALEM Abdellahi, RACHEDI Abdelkrim. STRUCTURAL/FUNCTIONAL MOTIFS IN THE ENZYMES OF THE KREBS CYCLE, 1ER SEMINAIRE DE BIOINFORMATIQUE, April 04-06, 2017, Blida, Algeria.

Citric Acid Cycle Binding Structural & Functional Motifs
- CacSFMs database-
Find CAC SFMs by Enzymes
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Find CAC SFMs by PDB entries
1AJ8   1IXE   2C6X   2P2W   2R9E   6CSC   1ACO   1FGH   1L5J   1ITW   1XKD   2UXR   4AJ3   4AJB   4BNP   3INM   4L06   4L04   4L03   4KZO   4AJR   4AJC   3O9Z   1CW4   2BWO   2BWN   2W8Q   4LH2   2DJL   3JU8   4APB   2DFD   
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Find CAC SFMs by Ligands
CIT   FLC   SDX   TRA   ATH   ICT   AKG   SCA   SIN   FUM   MLT   
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Ligand: IDFull NameFormula Chemistry
AKG2-OXOGLUTARIC ACIDC5 H6 O5AKG
There are 27 SFM Motifs:
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
33INMalpha-Ketoglutarate dehydrogenaseX-RAY2.100.220
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SHHLLH +1w
  > Sequence: TSNRRYDA
AKG
/(511)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SHHLLH +1w
  > Sequence: TSNRRYDA
AKG
/(511)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: SHHLLH +1w
  > Sequence: TSNRRYDA
AKG
/(511)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
64L06alpha-Ketoglutarate dehydrogenaseX-RAY2.280.227
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SSHLLH +1w
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
4 / D   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
5 / E   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
6 / F   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
64L04alpha-Ketoglutarate dehydrogenaseX-RAY2.870.200
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SSHSLLH
  > Sequence: TSNRRRDEA
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SSHLLH +1w
  > Sequence: TSNRRRDA
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: SSHLH
  > Sequence: TSNRRRD
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
4 / D   > Structure: SSHLH
  > Sequence: TNRRRD
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
5 / E   > Structure: SSHLLH
  > Sequence: TSNRRRDA
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
6 / F   > Structure: SSHLLH
  > Sequence: TSRRRDA
AKG
/(501)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
34L03alpha-Ketoglutarate dehydrogenaseX-RAY2.100.189
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SSHLLH +2w
  > Sequence: TSNRRRDA
AKG
/(504)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SSHLLH +2w
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: SSHLLH +3w
  > Sequence: TSNRRRDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
34KZOalpha-Ketoglutarate dehydrogenaseX-RAY2.200.178
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SHHLLH +2w
  > Sequence: TSNRRYDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SHHLLH +2w
  > Sequence: TSNRRYDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: SHHLLH +1w
  > Sequence: TSNRRYDA
AKG
/(503)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
14AJRalpha-Ketoglutarate dehydrogenaseX-RAY2.690.160
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LLHSSHHL
  > Sequence: LTSNRRRYDT
AKG
/(1418)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
14AJCalpha-Ketoglutarate dehydrogenaseX-RAY2.300.175
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: HSSHH +2w
  > Sequence: SNRRRYD
AKG
/(502)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
43O9Zalpha-Ketoglutarate dehydrogenaseX-RAY1.450.194
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LSLHHSL +2w
  > Sequence: KYTRNIHRF
AKG
/(312)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: LSLHHSL +3w
  > Sequence: KYTRNIHRF
AKG
/(312)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / C   > Structure: LSLHHSL +2w
  > Sequence: KYTRNIHRF
AKG
/(312)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
4 / D   > Structure: LSLHHSL +1w
  > Sequence: KYTRNHRF
AKG
/(312)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]