CacSFMs: Citric Acid Cycle Binding Structural & Functional Motifs - v. β May 2016.
© University Dr Tahar Moulay, Saida.



Project realized by:Abdalla Salem and Mubarka Khatir (in their project of MSc in Biology, 2015-2016)

Proposed & supervised by: Dr. Abdelkrim Rachedi, e-mail: rachedi@bioinformaticstools.org

Reference: SALEM Abdellahi, RACHEDI Abdelkrim. STRUCTURAL/FUNCTIONAL MOTIFS IN THE ENZYMES OF THE KREBS CYCLE, 1ER SEMINAIRE DE BIOINFORMATIQUE, April 04-06, 2017, Blida, Algeria.

Citric Acid Cycle Binding Structural & Functional Motifs
- CacSFMs database-
Find CAC SFMs by Enzymes
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Find CAC SFMs by PDB entries
1AJ8   1IXE   2C6X   2P2W   2R9E   6CSC   1ACO   1FGH   1L5J   1ITW   1XKD   2UXR   4AJ3   4AJB   4BNP   3INM   4L06   4L04   4L03   4KZO   4AJR   4AJC   3O9Z   1CW4   2BWO   2BWN   2W8Q   4LH2   2DJL   3JU8   4APB   2DFD   
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Find CAC SFMs by Ligands
CIT   FLC   SDX   TRA   ATH   ICT   AKG   SCA   SIN   FUM   MLT   
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Ligand: IDFull NameFormula Chemistry
SINSUCCINIC ACIDC4 H6 O4SIN
There are 9 SFM Motifs:
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
32BWNSUCCINYL-CoA-SynthetaseX-RAY2.100.161
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SLLLSLL
  > Sequence: RFPVWCGDTH
SIN
/(1398)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / D   > Structure: SLLLSLL +1w
  > Sequence: RFPVWCGDTH
SIN
/(1399)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
3 / E   > Structure: SLLLLSLL +1w
  > Sequence: RFPVWCGDYTSH
SIN
/(1400)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
12W8QSuccinic Semialdehyde DehydrogenaseX-RAY2.400.224
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: HLHSHLLL
  > Sequence: YFRERAVSF
SIN
/(3001)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
24LH2DELTA (1)-PYRROLINE-5-CARBOXYLATE DEHYDROGENASEX-RAY1.670.165
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LHLLL +2w
  > Sequence: NFKCSTGSF
SIN
/(602)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: LHLLL +2w
  > Sequence: NFKCSTGSF
SIN
/(602)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
22DJLSuccinate dehydrogenaseX-RAY1.380.166
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: SLLLSL +1w
  > Sequence: KNMGLPNCPNN
SIN
/(1370)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
2 / B   > Structure: SLLLSL +1w
  > Sequence: KNMGLPNCPNN
SIN
/(2370)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]
Nbr of Motifs
per PDB entry
PDB EntryTitleDetermination MethodResolutionR-Factor
13JU8SUCCINYLGLUTAMIC SEMIALDEHYDE DEHYDROGENASEX-RAY1.820.160
Motif No./ChainModeBound Ligand
/(Nbr. in PDB)
Show Details
1 / A   > Structure: LHLLS
  > Sequence: NFLRCTTGAF
SIN
/(504)
[+]
  > Graphics rep1: [+]
  > Graphics rep2: [+]
  > Graphics rep3: [+]